What 1-AD has to offer: High oral activity, conversion to a
hormone 700% more potent than testosterone,absolutely NO
aromatization to estrogens natural and safe!
There can be no argument that ErgoPharm 1-AD is the ultimate
This compound is truly unique amongst other prohormones in a
variety of ways.
1 AD The Future of Prohormones
You are about to be introduced to the future of prohormones. It is
called 1-AD, and it is without a doubt the single
most amazing prohormone to be synthesized and sold as a nutritional
Lets start by setting something straight. They are not
amateurs to the prohormone industry. On the contrary, They actually
started the whole prohormone industry. But not only that, They are
also responsible for practically every significant innovation in
prohormone technology to date. The leader of ErgoPharm, organic
chemist Patrick Arnold, was the person who discovered
androstenedione and introduced it to the market in 1996. Patrick
also discovered and patented Androdiol® (4-androstenediol) and
Norandrodiol® (19-nor-4-androstenediol), and introduced
cyclodextrin technology to the prohormone industry.
For the past 18 months Patrick has been feverishly working
almost exclusively on one project. While scores of less
knowledgeable people in the industry periodically made occasional
lame, foul ball attempts at finding the latest,
greatest prohormone, Patrick kept quiet and worked on the
development of what essentially could be called the holy
grail of prohormones.
Patrick wanted this prohormone to have all the attributes most
critical to the perfect prohormone.It had to be:
- Orally Active
- Completely Non-Aromatizable
- Extremely potent
- Naturally occurring
After months of scouring
every book and journal he could locate, including those in foreign
languages (i.e. German), Patrick discovered a compound that seemed
to be the perfect candidate. That was the easy part. It then took
Patrick almost one whole year to figure out how to manufacture the
compound cheaply enough for sale as a supplement. Patricks
lab took on the appearance of ground zero at Hiroshima as he
endlessly did reaction after reaction in pursuit of the perfect
Before They introduce exactly what 1-AD is, They want to mention
one quick thing. In this industry it is often hard to find straight
answers to exactly what something is, and how something works. Most
often, the case is that the company is evasive with the facts
because there really is no existing science that validates the
claims they are making. Either that or they simply do not
understand the science themselves. Occasionally a company does have
science to back up their products, but they decide that the
consumer is too simple minded to appreciate the facts.
ErgoPharm is different. They produce products that are backed up
by hard scientific fact, and They take great pride in laying
everything on the table.
They understand that not everyone buying our products has a
chemistry or biology degree, but They do know that people
appreciate being treated with respect and honesty. They want to
know they are being told the straight story, even if they
dont have the background to understand every facet of the
Its time to introduce what Patrick refers to as the
crown achievement of his career. The formal chemical name of
the compound Patrick developed is 1-androstene-3beta, 17beta-diol.
They nicknamed this compound 1-AD which is a shortened
acronym of its chemical name. Its chemical structure is:
This compound is truly unique amongst other prohormones in a
variety of ways. Lets look specifically at 1-AD and what it
The PoTheyr of
You probably are familiar with the Andro prohormones,
and the Norandro prohormones. The former convert to
testosterone and the latter to 19-nortestosterone. 1-AD, however,
does not fit into either of those categories. That is because 1-AD
converts to a relatively unheard of hormone called 1-testosterone.
1-testosterone is what is known as a double bond isomer
Although chemically the only
difference between testosterone and 1-testosterone is the position
of the double bond, pharmacologically the two products are quite
different. According to research done by the pharmaceutical giant
G.D. Searle and published in the 1960s, 1-testosterone is over 7
times as myotrophic (anabolic) as testosterone. That makes
1-testosterone a phenomenally potent compound, surpassing even most
synthetic anabolic steroids.
1-testosterone differs from testosterone in another way as well.
Being a 5alpha-reduced androgen (a DHT derivative) it simply cannot
aromatize to estrogens. The same goes for 1-AD itself no
estrogen transformation can occur. This makes 1-AD unique compared
to other prohormones all of which can either aromatize
directly, convert to a product that aromatizes, or both. So what
does this mean in the real world? It means that your chances of
getting gynecomastia (bitch tits) from 1-AD is essentially zero,
and that water retention side effects are vastly reduced compared
to other prohormones.
The Only Truly Orally Active Prohormone
Natural androgenic steroids are normally not very active orally.
Large amounts have to be taken orally to see biological effects.
This is because the first pass through the liver causes a massive
deactivation of the compounds, primarily through the oxidation of
the 17beta-hydroxyl to a 17-keto group. Chemists long ago found
that by adding an alkyl (methyl or ethyl) chemical group to the
alpha position of the 17 carbon, this oxidation can be prevented.
However, this alkyl derivatization also greatly increases the liver
toxicity. Therefore the usage of such synthetically altered
compounds (methyltestosterone, oxymetholone, stanozolol) are not
without substantial risk.
Luckily, there are other ways to render a steroid orally active,
and do so without making the compound toxic to the liver. Certain
structural modifications can alter the metabolism of steroids
making them resistant to liver breakdown. One of these
modifications is unsaturation (presence of a double bond) in the
1-position. One steroid that has this structural modification and
is orally active is the anabolic steroid Methenolone, also known as
This double bond position
that makes Primobolan orally active is the same one found in 1-AD,
which, by the way, is also orally active. Steroids with this
particular double bond characteristic are known as
During the 60s and 70s some papers Theyre published
describing the phenomenon of oral activity seen with
1-dehydroandrostanes, including 1-testosterone and 1-AD. What was
discovered was that these compounds resist metabolic deactivation
by profoundly shifting what is known as the 17-keto redox
potential towards the formation of active 17beta-hydroxyl
steroids(2,3). What does this mean? It means that when you take
1-AD, the liver serves primarily to activate the compound, rather
than break it down and excrete it as it does with other prohormones
and testosterone. It means that 1-AD is orally active,
yet it does not impart the liver toxicity that 17alpha-alkylation
A Natural Hormone Made in
One of the beautiful things about 1-AD is that in addition to its
impressive pharmacological activity, it is also a natural androgen
made in the human body(4) . This means that it is not foreign to
your body, and that it can legally and openly be sold as a
nutritional supplement. Furthermore, 1-ADs high rate of
active conversion after oral administration is not just a
theory of ErgoPharms it has been
demonstrated and published in a highly reputable peer reviewed
Lets put it all together and see what 1-AD has to
- High oral activity
- Conversion to a hormone
700% more potent than testosterone
- Absolutely NO aromatization
- Natural and safe
There can be no argument
that this is the ultimate prohormone. Believe us, there simply are
no natural compounds out there that can come close to what 1-AD
does, so dont even bother looking.
1.Counsel et al., Anabolic Agents. Derivatives of
5alpha-Androst-1-ene, J. Org. Chem., 27 (1962), 248-251
2. Galletti and Gardi, Metabolism of 1-Dehydroandrostanes in
Man, J Steroid Biochem, 3 (1972), 933-936
3. Langecker, Beziehungen Zwischen Substitution im Ring A
und Abbau im StoffTheychsel bei Verwandten des Testosterons,
Acta Endocrin, 41 (1962), 494-506
4. Lieberman et al., J. Biol. Chem, 182 (1950), 299
5. Galletti and Gardi, Metabolism of 1-Dehydroandrostanes in
Man, J Steroid Biochem, 3 (1972), 933-936
Testosterone is the most important sex hormone in the male body,
and it plays a key role in keeping men physically and
psychologically healthy. Testosterone is involved in numerous roles
- Increasing and preserving
- Maintaining both sexual
drive and performance
- Heightened mood and energy
The male body makes
testosterone both in the testes and in the outer layer of the
adrenal glands (called the adrenal cortex). In the females, the
ovaries are responsible for producing small quantities of
The Perils of Lowered
As men age, two things may happen with respect to testosterone:
(1) the male ability to produce testosterone declines, and (2)
blood levels of free testosterone decline, making less testosterone
available to tissues, such as muscles. If testosterone levels fall
below normal, symptoms such as reduced lean body mass, loss of
libido, erectile dysfunction, decreased bone density, depression
and fatigue can occur. Men may experience irritability, inability
to concentrate and depression.
If left untreated, low testosterone could significantly decrease
quality of life and cause additional medical complications.
Subnormal Testosterone levels can also adversely affect
relationships; ability and desire to participate in normal
activities (both sexual and social) due to depression and fatigue;
and low self esteem due to a decrease in masculine characteristics,
such as lean body mass, increased breast size and less facial or
Serving Size (caps) 1
Servings Per 60
Other ingredients: micro crystalline cellulose.
1 AD Suggested Use:
Take 1-3 caps 3 times daily with food. Do not break open caps and
do not exceed recommended dosage.
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